The Division of Birth Defects and Developmental Disabilities in the Centers for Disease Control and Prevention (CDC) provides technical and administrative oversight to the Centers for Birth Defects Research and Prevention (CBDRP). The CDC also participates in the National Birth Defects Prevention Study (NBDPS) as the Georgia study center.
The CDC has monitored birth defects and genetic diseases in Atlanta since 1968 through the Metropolitan Atlanta Congenital Defects Program (MACDP) surveillance system. MACDP provides data collection on all major structural birth defects and serves as a model for other state surveillance systems. It also provides the Georgia study center with cases for NBDPS and the diagnostic information to classify cases.
The Georgia study center has allowed CDC to strengthen its research agenda, particularly in gene-environment interaction studies and to maximize the use of CDC staff members’ expertise. By participating in the NBDPS, more than 3,000 women from Georgia have helped us to understand the causes of birth defects. For more information on the Georgia study center, please visit the website.
Jennita Reefhuis, PhD, is the Project Officer for the Centers for Birth Defects Research and Prevention and a Co-Principal Investigator for the Georgia study center. As the project officer for the CBDRP, Dr. Reefhuis coordinates the collaboration between the different centers who work together in the study. As one of the Georgia co-principal investigators, she works to make sure the Georgia site is interviewing as many women as we can. She also does research with the data and writes papers about the findings...Read More
Sarah Tinker, PhD, is a Co-Principal Investigator for the Georgia study center. As a co-PI for the Georgia study center, Dr. Tinker is focused on the collection of high quality data from local study subjects. She works with those involved in case and control identification, interviewing, and cheek cell collection to ensure that the process is running smoothly…Read More
Local Activities and Research:
Prospective Study of Children Born with Spina Bifida: The purpose of this project is to increase the knowledge about the natural history of spina bifida. The study will include children with spina bifida aged 3-5 years, and families will either complete a phone survey or an in-person interview. The study hopes to collect information relating to medical concerns prevalent among children with spina bifida, development and learning, nutrition and physical growth, mobility and functioning, general health, and family demographics.
Stillbirth Surveillance Pilot Project: CDC has initiated stillbirth surveillance activities in its own system and has provided funding to the Iowa Department of Public Health to conduct these activities as part of its birth defects surveillance system. The purpose of this project is to evaluate the feasibility of expanding the birth defects surveillance system to incorporate data on all stillbirths, those with and without identifiable malformations, among residents in the study population; to monitor and report on the occurrence of stillbirths in the population; to serve as a registry for hypotheses driven etiologic studies on stillbirth; and to serve as a resource for education and evaluation of targeted prevention strategies.
Molecular Genetics Laboratory, National Center for Environmental Health, CDC
Georgia Department of Health
March of Dimes
Polen KND, Rasmussen SA, Riehle-Colarusso T, Reefhuis J, National Birth Defects Prevention Study. The association between reported venlafaxine use in early pregnancy and birth defects, National Birth Defects Prevention Study, 1997-2007. Birth Defects Res A Clin Mol Teratol 2013;97(1):28-35.
Correa A, Gilboa SM, Botto LD, Moore CA, Hobbs CA, Cleves MA, Riehle-Colarusso TJ, Waller DK, Reece EA, National Birth Defects Prevention Study. Lack of periconceptional vitamins or supplements that contain folic acid and diabetes mellitus-associated birth defects. American Journal of Obstetrics and Gynecology. 2012; 206(3):218e1-218e13.
Gilboa SM, Desrosiers TA, Lawson C, Lupo PJ, Riehle-Colarusso TJ, Stewart PA, van Wijngaarden E, Waters MA, Correa A, National Birth Defects Prevention Study. Association between maternal occupational exposure to organic solvents and congenital heart defects, National Birth Defects Prevention Study, 1997-2002. Occupational and Environmental Medicine. 2012; 69(9):628-635.
Gill SK, Broussard C, Devine O, Green RF, Rasmussen SA, Reefhuis J, National Birth Defects Prevention Study. Association between maternal age and birth defects of unknown etiology - United States, 1997-2007. Birth Defects Research (Part A): Clinical and Molecular Teratology. 2012; 94(12):1010-1018.
Alwan S, Reefhuis J, Rasmussen SA, Friedman JM. Patterns of antidepressant medication use among pregnant women in a United States population. Journal of Clinical Pharmacology. 2011; 51(2):264-270.
Broussard CS, Rasmussen SA, Reefhuis J, Friedman JM, Jann MW, Riehle-Colarusso T, Honein MA; National Birth Defects Prevention Study. Maternal treatment with opioid analgesics and risk for birth defects. American Journal of Obstetrics and Gynecology. 2011; 204(4):314.e1-314.e11..
Gallagher ML, Sturchio C, Smith A, Koontz D, Jenkins MM, Honein MA, Rasmussen SA. Evaluation of mailed pediatric buccal cytobrushes for use in a case-control study of birth defects. Birth Defects Research (Part A): Clinical and Molecular Teratology. 2011; 91(7):642-648.
Hartman RJ, Riehle-Colarusso T, Lin A, Frías JL, Patel SS, Duwe K, Correa A, Rasmussen SA; The National Birth Defects Prevention Study. Descriptive study of nonsyndromic atrioventricular septal defects in the National Birth Defects Prevention Study, 1997-2005. American Journal of Medical Genetics. Part A. 2011; 155A(3):555-564.
Jenkins MM, Reed-Gross E, Barfield WD, Prue CE, Gallagher ML, Rasmussen SA, Honein MA. Qualitative assessment of study materials and communication strategies used in studies that include DNA collection. American Journal of Medical Genetics. Part A. 2011; 155A(11):2721-2731.
Rasmussen SA, Riehl-Colarusso T, Shapira SK, Honein MA, Reefhuis J. Letter to the editor: Ventricular septal defects and the National Birth Defects Prevention Study. Birth Defects Research (Part A): Clinical and Molecular Teratology. 2011; 91(1):66.
Reefhuis J, Honein MA, Schieve LA, Rasmussen SA. Use of clomiphene citrate and birth defects, National Birth Defects Prevention Study, 1997-2005. Human Reproduction. 2011; 26(2):451-457.
Reefhuis J, Rasmussen SA, Honein MA, National Birth Defects Prevention Study. Prenatal versus postnatal repair of myelomeningocele. New England Journal of Medicine. 2011; 364(26):2555.
Tinker SC, Reefhuis J, Dellinger AM, Jamieson DJ. Maternal injuries during the periconceptional period and the risk of birth defects, National Birth Defects Prevention Study, 1997-2005. Paediatric and Perinatal Epidemiology. 2011; 25(5):487-496.