The Division of Birth Defects and Developmental Disabilities in the Centers for Disease Control and Prevention (CDC) provides technical and administrative oversight to the Centers for Birth Defects Research and Prevention (CBDRP). The CDC also coordinates the National Birth Defects Prevention Study (NBDPS) data management and analyses and serves as the Georgia study site. CDC brings a lot of experience, like studying medication use among pregnant women and finding new ways to look at the data. In addition, CDC keeps track of birth defects in Atlanta through the Metropolitan Atlanta Congenital Defects Program (MACDP). MACDP has collected data in Atlanta since 1968 and serves as a model for other state surveillance system.
By participating in the NBDPS, more than 3,000 women from Georgia have helped us to understand the causes of birth defects. For more information on the Georgia study center, please visit the website.
Jennita Reefhuis, PhD, is the Project Officer for the Centers for Birth Defects Research and Prevention and a Co-Principal Investigator for the Georgia study center. As the project officer for the CBDRP, Dr. Reefhuis coordinates the collaboration between the different centers who work together in the study. As one of the Georgia co-principal investigators, she works to make sure the Georgia site is interviewing as many women as we can. She also does research with the data and writes papers about the findings...Read More
Sarah Tinker, PhD, is a Co-Principal Investigator for the Georgia study center. As a co-PI for the Georgia study center, Dr. Tinker is focused on the collection of high quality data from local study subjects. She works with those involved in case and control identification, interviewing, and cheek cell collection to ensure that the process is running smoothly…Read More
Local Activities and Research:
Prospective Study of Children Born with Spina Bifida: The purpose of this project is to increase the knowledge about the natural history of spina bifida. The study will include children with spina bifida aged 3-5 years, and families will either complete a phone survey or an in-person interview. The study hopes to collect information relating to medical concerns prevalent among children with spina bifida, development and learning, nutrition and physical growth, mobility and functioning, general health, and family demographics.
Stillbirth Surveillance Pilot Project: CDC has initiated stillbirth surveillance activities in its own system and has provided funding to the Iowa Department of Public Health to conduct these activities as part of its birth defects surveillance system. The purpose of this project is to evaluate the feasibility of expanding the birth defects surveillance system to incorporate data on all stillbirths, those with and without identifiable malformations, among residents in the study population; to monitor and report on the occurrence of stillbirths in the population; to serve as a registry for hypotheses driven etiologic studies on stillbirth; and to serve as a resource for education and evaluation of targeted prevention strategies.
Molecular Genetics Laboratory, National Center for Environmental Health, CDC
Georgia Department of Health
March of Dimes
Arth A, Tinker S, Moore C, Canfield M, Agopian A, Reefhuis J. Supplement use and other characteristics among pregnant women with a previous pregnancy affected by a neural tube defect-United States, 1997-2009. MMWR Morb Mortal Wkly Rep. 2015 Jan 16;64(1):6-9.
Ailes EC, Gilboa SM, Riehle-Colarusso T, Johnson CY, Hobbs CA, Correa A, Honein MA, and the National Birth Defects Prevention Study. Prenatal diagnosis of nonsyndromic congenital heart defects. Prenatal Diagnosis. 2014; 34(3):214-222. Epub 2013 Dec 17.
Dawson AL, Riehle-Colarusso T, Reefhuis J, Arena JF, and the National Birth Defects Prevention Study. Maternal Exposure to Methotrexate and Birth Defects: A Population-Based Study. Am J Med Genet Part A. 2014 Sep;164A(9):221206.
Dawson AL, Tinker SC, Jamieson DJ, Hobbs CA, Rasmussen SA, Reefhuis J and the National Birth Defects Prevention Study. Epidemiology of twinning in the National Birth Defects Prevention Study, 1997 to 2007. Res A Clin Mol Teratol. 2014 Oct 31.
Gilboa SM, Lee KA, Cogswell ME, Traven FK, Botto LD, Riehle-Colarusso T, Correa A, Boyle CA, and the National Birth Defects Prevention Study. Maternal Intake of Vitamin E and Birth Defects, National Birth Defects Prevention Study, 1997 to 2005. Birth Defects Res A Clin Mol Teratol. 2014 Sep;100(9):647-57.
Glidewell J, Reefhuis J, Rasmussen SA, Woomert A, Hobbs C, Romitti PA, Crider KS. Factors affecting maternal participation in the genetic component of the NBDPS — United States, 1997-2007. Genet Med. 2014 Apr;16(4):329-37.
Jenkins MM, Reefhuis J, Gallagher ML, Mulle JG, Hoffmann TJ, Koontz DA, Sturchio C, Rasmussen SA, Witte JS, Richter P, Honein MA, and the National Birth Defects Prevention Study. Maternal Smoking, Xenobiotic Metabolizing Enzyme Gene Variants, and Gastroschisis Risk. Am J Med Genet Part A. 2014; 9999:1-10.
Peterson C, Ailes E, Riehle-Colarusso T, Oster ME, Olney RS, Cassell CH, Fixler DE, Carmichael SL, Shaw GM, Gilboa SM. Late Detection of Critical Congenital Heart Disease Among US Infants: Estimation of the Potential Impact of Proposed Universal Screening Using Pulse Oximetry. JAMA Pediatr. 2014 April;168(4):361-370.